𝛃2 microglobulin

𝛃2 microglobulin in the glossary for Waldenström's macroglobulinemia

Beta-2-microglobulin is a small membrane protein associated with the heavy chains of class I major histocompatibility complex (MHC) proteins and is, therefore, on the surface of all nucleated cells (excludes red blood cells).

Beta-2-microglobulin is a small membrane protein associated with the heavy chains of class I major histocompatibility complex (MHC) proteins and is, therefore, on the surface of all nucleated cells. Levels are elevated in renal dysfunction. Pathologies with high cell turnover, such as hemato-oncological conditions, and rheumatologic diseases are also associated with higher serum β2M levels. ¹

Glossary overview

References

1.Argyropoulos CP, Chen SS and Ng Y, et al. Rediscovering Beta-2 Microglobulin as a Biomarker across the Spectrum of Kidney Diseases. Frontiers in Medicine 2017: 4(73);1-25.

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