Up-to-date Information on
Waldenström’s macroglobulinemia



The state-of-the-art glossary for Waldenström’s macroglobulinemia.


Bortezomib in the glossary for Waldenström's macroglobulinemia

Bortezomib is a proteosome inhibitor.

Bortezomib is a reversible inhibitor of the chymotrypsin-like activity of the 26S proteasome in mammalian cells.1 Inhibition of the proteasome results in cell cycle arrest and apoptosis. Bortezomib is administered as monotherapy or in combination with pegylated liposomal doxorubicin or dexamethasone. Bortezomib is indicated for the treatment of multiple myeloma and mantle cell lymphoma. Bortezomib was approved for medical use in the European Union in 2004.2

Glossary overview


1.Bortezomib SmPC. Available from; https://www.ema.europa.eu/en/documents/product-information/velcade-epar-product-information_en.pdf. Accessed November 12th, 2021.
2.EMEA Scientific Discussion – Bortezomib. Available from; https://www.ema.europa.eu/en/documents/scientific-discussion-variation/velcade-h-c-539-ii-0005-epar-scientific-discussion-variation_en.pdf. Accessed November 12th, 2021.
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