Bruton's tyrosine kinase (BTK)

Bruton's tyrosine kinase (BTK) in the glossary for Waldenström's macroglobulinemia

Is a non-receptor kinase that plays a crucial role in oncogenic signaling that is critical for proliferation and survival of leukemic cells in many B-cell malignancies.

BTK is a key compenent of the BCR signalling pathway. Stimulation of the BCR in mature B cells induces tyrosine phosphorylation of BTK. Additionally, BTK plays a crucial role in B cell development as it is required for transmitting signals from the pre-B-cell receptor that forms after successful immunoglobulin heavy chain rearrangement, thereby providing signals for survival, proliferation and differentiation. ^1,2

Glossary overview

References

1.Pal Singh S, Dammeijer F and Hendriks RW. Role of Bruton’s tyrosine kinase in B cells and malignancies. Molecular Cancer 2018: 17;57.

2.Hendriks RW, Yuvaraj S, Kil LP. Targeting Brutons tyrosine kinase in B cell malignancies. Nat Rev Cancer 2014: 14(4);219-232.

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