Glossary
The state-of-the-art glossary for Waldenström’s macroglobulinemia.
Cyclophosphamide
Cyclophosphamide in the glossary for Waldenström's macroglobulinemia
An immunosuppressive alkylating agent (chemotherapy).
Cyclophosphamide (also known as cytophosphane) used as a chemotherapeutic1 and immunosuppressive agent. 2 As chemotherapy, it is used to treat a range of cancers, including lymphoma, multiple myeloma, leukemia, breast cancer and small cell lung cancer. As an effective immunosuppressive agent, cyclophosphamide multiple studies have found cyclophosphamide useful in the treatment of autoimmune diseases such as multiple sclerosis. Cyclophosphamide has also been prescribed pretransplant as an immunosuppressant to prevent transplant rejection and graft-vs-hostcomplications.1 It is administered orally or intravenously. Cyclophosphamide is in the alkylating agent and nitrogen mustard family of medications and exerts its effect by interfering with the synthesis of RNA and the duplication of DNA.1 Cyclophosphamide was approved for medical use in the United States (US) in 1959. 2. Cyclophosphamide is authorized for use in the EU.3
Glossary overview