Up-to-date Information on
Waldenström’s macroglobulinemia



The state-of-the-art glossary for Waldenström’s macroglobulinemia.


M-protein in the glossary for Waldenström's macroglobulinemia

An abnormal antibody (immunoglobulin) or fragment thereof, produced in excess by abnormal monoclonal proliferation of plasma cells.

M-proteins are immunoglobulins produced in excess by an abnormal clonal proliferation of B-cells or plasma cells. Excessive M-protein production is characteristic of a group of disorders termed monoclonal gammopathies, paraproteinaemias, or plasma cell dyscrasias. These disorders comprise a spectrum of premalignant and malignant hematological conditions and include MGUS, Waldenström’s macroglobulinemia and multiple myeloma.1

Glossary overview


1.Pruppers MHJ, Merkies ISJ, Notermans NC, et al. Chapter 5 - Monoclonal gammopathy associated neuropathy: Focusing on IgM M-protein associated neuropathy. Dysimmune Neuropathies 2020; Academic Press.
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