MAG antibodies

MAG antibodies in the glossary for Waldenström's macroglobulinemia

MAG antibodies (myelin-associated glycoprotein antibodies) – Frequently associated with, and contribute directly to, the pathogenesis of peripheral neuropathies. These autoantibodies frequently occur with IgM paraproteinemia.

Myelin-associated glycoprotein (MAG) is a type of glycoprotein found within the myelin sheath and in Schwann cells, which are responsible for creating and maintaining myelin sheaths on nerve axons. MAG antibodies (myelin-associated glycoprotein antibodies) are frequently associated with, and contribute directly to, the pathogenesis of peripheral neuropathies. In anti-MAG neuropathy the monoclonal gammopathy is IgM. MAG antibodies also frequently occur with IgM paraproteinemia.¹

Glossary overview

References

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