Nucleoside analogues

Nucleoside analogues in the glossary for Waldenström's macroglobulinemia

Synthetic, chemically modified nucleosides that mimic their physiological counterparts (endogenous nucleosides) and block cellular division or viral replication by impairing DNA/RNA synthesis or by inhibition of cellular or viral enzymes involved in nucleoside/tide metabolism.

Nucleoside analogues are synthetic, chemically modified nucleosides that mimic their physiological counterparts (endogenous nucleosides) and block cellular division or viral replication by impairing DNA/RNA synthesis or by inhibition of cellular or viral enzymes involved in nucleoside/tide metabolism. Nucleoside analogues are essential components of acute myeloid leukemia (AML) induction therapy (cytosine arabinoside), effective treatments of lymphoproliferative disorders (fludarabine, cladribine) and are also used in the treatment of some solid tumors (gemcitabine).^1,2

Glossary overview

References

1.The American Heritage® Medical Dictionary© 2007. 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. Available from; https://medical-dictionary.thefreedictionary.com/. Accessed November 12th, 2021.

2.Galmarini, C., Mackey, J. & Dumontet, C. Nucleoside analogues: mechanisms of drug resistance and reversal strategies. Leukemia 2001: 15;875–890

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